Smell impairment in workers occupationally exposed to cadmium

Acta Otolaryngol. 2000 Mar;120(2):316-8. doi: 10.1080/000164800750001161.

Abstract

ENT and olfactometric examinations were carried out on 73 workers at an electrochemical plant involved in the production of cadmium-nickel batteries, where cadmium fumes were emitted into the workplace. Exposure levels exceeded the maximum allowable concentrations by about 1-2 times. The controls included 43 non-exposed, age- and cigarette-smoking-matched people. The olfactometric tests were carried out by the blast injection method, using natural coffee, aniseed, lemon and mint oils; two threshold measurements were assessed: maximum perceptible odour (MPO) and minimum identifiable odour (MIO). In addition, blood chemistries and urinalysis were carried out. The study revealed the smell lesion in 45.2% of the exposed group vs 4.6% of the controls. A statistically significant correlation between olfactory dysfunction and cadmium concentrations in the blood and urine was found; however, no correlation with the duration of employment was observed. It seems most likely that cigarette smoking, which is a considerable source of cadmium, may intensify this dysfunction, hence heavy smokers should not work in conditions of cadmium exposure.

MeSH terms

  • Adult
  • Air Pollutants, Occupational / adverse effects*
  • Cadmium / adverse effects*
  • Cadmium / pharmacokinetics
  • Cadmium Poisoning / diagnosis*
  • Dose-Response Relationship, Drug
  • Drug Synergism
  • Electrochemistry
  • Humans
  • Middle Aged
  • Occupational Diseases / diagnosis*
  • Odorants
  • Olfaction Disorders / chemically induced*
  • Olfaction Disorders / diagnosis
  • Risk Factors
  • Sensory Thresholds / drug effects
  • Smoking / adverse effects

Substances

  • Air Pollutants, Occupational
  • Cadmium