Synthesis and antimycobacterial activity of 5-aryl-1-isonicotinoyl-3-(pyridin-2-yl)-4, 5-dihydro-1H-pyrazole derivatives

M G Mamolo; D Zampieri; V Falagiani; L Vio; E Banfi

Synthesis and antimycobacterial activity of 5-aryl-1-isonicotinoyl-3-(pyridin-2-yl)-4, 5-dihydro-1H-pyrazole derivatives

Farmaco. 2001 Aug;56(8):593-9.

Authors

M G Mamolo¹, D Zampieri, V Falagiani, L Vio, E Banfi

Affiliation

¹ Dipartimnento di Scienze Farmaceutiche, Università di Trieste, Italy. mamolo@univ.trieste.it

PMID: 11601645

Abstract

5-Aryl-1-isonicotinoyl-3-(pyridin-2-yl)-4,5-dihydro-1H-pyrazole derivatives were synthesized and tested for their in vitro antimycobacterial activity. The compounds showed an interesting activity against a strain of Mycobacterium tuberculosis and a human strain of M. tuberculosis H4.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Anti-Bacterial Agents / chemical synthesis*
Anti-Bacterial Agents / chemistry
Anti-Bacterial Agents / pharmacology
Antitubercular Agents / chemical synthesis*
Antitubercular Agents / chemistry
Antitubercular Agents / pharmacology
Humans
Microbial Sensitivity Tests
Mycobacterium tuberculosis / drug effects
Mycobacterium tuberculosis / isolation & purification
Pyrazoles / chemical synthesis*
Pyrazoles / chemistry
Pyrazoles / pharmacology
Structure-Activity Relationship

Substances

Anti-Bacterial Agents
Antitubercular Agents
Pyrazoles