Synthesis and antimycobacterial activity of [5-(pyridin-2-yl)-1,3,4-thiadiazol-2-ylthio]acetic acid arylidene-hydrazide derivatives

M G Mamolo; V Falagiani; D Zampieri; L Vio; E Banfi

doi:10.1016/s0014-827x(01)01097-7

Synthesis and antimycobacterial activity of [5-(pyridin-2-yl)-1,3,4-thiadiazol-2-ylthio]acetic acid arylidene-hydrazide derivatives

Farmaco. 2001 Aug;56(8):587-92. doi: 10.1016/s0014-827x(01)01097-7.

Authors

M G Mamolo¹, V Falagiani, D Zampieri, L Vio, E Banfi

Affiliation

¹ Dipartimento di Scienze Farmaceutiche, Università, di Trieste, Italy. mamolo@univ.trieste.it

PMID: 11601644
DOI: 10.1016/s0014-827x(01)01097-7

Abstract

[5-(Pyridin-2-yl)-1,3,4-thiadiazol-2-ylthio]acetic acid arylidene-hydrazide derivatives were synthesized and tested for their in vitro antimycobacterial activity. Some compounds showed a feable activity against a strain of Mycobacterium tuberculosis and a strain of Mycobacterium avium.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Anti-Bacterial Agents / chemical synthesis*
Anti-Bacterial Agents / chemistry
Anti-Bacterial Agents / pharmacology
Microbial Sensitivity Tests
Mycobacterium / drug effects
Structure-Activity Relationship
Thiadiazoles / chemical synthesis*
Thiadiazoles / chemistry
Thiadiazoles / pharmacology

Substances

Anti-Bacterial Agents
Thiadiazoles