[Protective effect of Astragalus membranaceus (Fisch.) Bge. and Hedysarum polybotrys Hand.-Mazz. on experimental model of cerebral ischemia in rats]

Zhongguo Zhong Yao Za Zhi. 1998 Jun;23(6):371-3, inside back cover.
[Article in Chinese]

Abstract

The experimental model of middle cerebral artery embolism in rats was made by inserting nylon thread. It was discovered that Astragalus membranaceus decoction(both 4.26 g.kg-1 and 7.1 g.kg-1) could reduce the capillary hyperpermeability and alleviate the dyskinesia caused by cerebral ischemia in rats. Purified Hedysarum polybotrys decoction (waste substances removed with alcohol after decocting with water) (12.5 g.kg-1) could reduce the water content in brain caused by occlusion of bilateral carotids in rats. Purified Hedysarum polybotrys decoction showed a tendency to reduce the water content in brain, but without statistical significance.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Astragalus propinquus
  • Brain Edema / drug therapy
  • Brain Ischemia / drug therapy
  • Brain Ischemia / physiopathology*
  • Capillary Permeability / drug effects
  • Drugs, Chinese Herbal / classification
  • Drugs, Chinese Herbal / pharmacology*
  • Fabaceae / classification
  • Fabaceae / therapeutic use*
  • Male
  • Movement Disorders / drug therapy
  • Neuroprotective Agents / pharmacology*
  • Phytotherapy*
  • Plants, Medicinal*
  • Random Allocation
  • Rats
  • Rats, Wistar

Substances

  • Drugs, Chinese Herbal
  • Neuroprotective Agents