A platinum(IV) complex oxidizes guanine to 8-oxo-guanine in DNA and RNA

Inorg Chem. 2001 Oct 22;40(22):5481-2. doi: 10.1021/ic015549t.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Antineoplastic Agents / chemistry*
  • Antineoplastic Agents / pharmacology
  • Chromatography, High Pressure Liquid
  • DNA / chemistry*
  • DNA / drug effects
  • DNA Damage
  • Deoxyguanine Nucleotides / chemistry
  • Electrochemistry
  • Guanine / analogs & derivatives*
  • Guanine / chemistry*
  • Guanosine Monophosphate / chemistry
  • Organoplatinum Compounds / chemistry*
  • Organoplatinum Compounds / pharmacology
  • Oxidation-Reduction
  • RNA / chemistry*
  • RNA / drug effects

Substances

  • Antineoplastic Agents
  • Deoxyguanine Nucleotides
  • Organoplatinum Compounds
  • dichloro-1,2-diaminocyclohexane platinum complex
  • 8-hydroxyguanine
  • Guanine
  • RNA
  • 2'-deoxyguanosine 5'-phosphate
  • Guanosine Monophosphate
  • DNA