Oligonucleotides containing a lysine residue as 3'-3' junction for alternate strand triple helix formation

Bioorg Med Chem. 2001 Nov;9(11):2895-900. doi: 10.1016/s0968-0896(01)00164-x.

Abstract

Oligonucleotides with a 3'-3' inversion of polarity site assured by one lysine residue have been synthesized, characterized and used as third strands in alternate strand triple helix formation. UV melting studies and molecular mechanics calculations have been carried out to investigate the stability and the geometry of these new triplexes.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Base Sequence
  • DNA / chemistry*
  • Drug Stability
  • Lysine / chemistry*
  • Models, Molecular
  • Nucleic Acid Conformation
  • Oligonucleotides / chemistry*
  • Spectrum Analysis
  • Temperature

Substances

  • Oligonucleotides
  • triplex DNA
  • DNA
  • Lysine