Two episodes of leukoencephalitis associated with recombinant hepatitis B vaccination in a single patient

D Konstantinou; C Paschalis; T Maraziotis; P Dimopoulos; H Bassaris; A Skoutelis

doi:10.1086/322617

Two episodes of leukoencephalitis associated with recombinant hepatitis B vaccination in a single patient

Clin Infect Dis. 2001 Nov 15;33(10):1772-3. doi: 10.1086/322617. Epub 2001 Oct 10.

Authors

D Konstantinou¹, C Paschalis, T Maraziotis, P Dimopoulos, H Bassaris, A Skoutelis

Affiliation

¹ Department of Neurosurgery, Patras University Medical School, Rio, Patra, Greece.

PMID: 11595974
DOI: 10.1086/322617

Abstract

Cases of central nervous system demyelination have been reported after recombinant hepatitis B vaccination, but no causal link has been clearly demonstrated. We present the first case report involving the occurrence of 2 episodes of leukoencephalitis in a previously healthy patient after vaccination and rechallenge with hepatitis B vaccine.

Publication types

Case Reports

MeSH terms

Adult
Brain / diagnostic imaging
Female
Hepatitis B / genetics
Hepatitis B / prevention & control
Hepatitis B Vaccines / adverse effects*
Hepatitis B virus / immunology
Humans
Leukoencephalitis, Acute Hemorrhagic / chemically induced*
Leukoencephalitis, Acute Hemorrhagic / diagnostic imaging*
Magnetic Resonance Imaging
Radiography
Recombination, Genetic / genetics
Vaccination

Substances

Hepatitis B Vaccines