Nanomolar E-selectin inhibitors: 700-fold potentiation of affinity by multivalent ligand presentation

J Am Chem Soc. 2001 Oct 17;123(41):10113-4. doi: 10.1021/ja0164430.
No abstract available

MeSH terms

  • Carbohydrate Sequence
  • E-Selectin / metabolism
  • E-Selectin / physiology*
  • Endothelium, Vascular / cytology
  • Endothelium, Vascular / drug effects
  • Humans
  • Ligands
  • Molecular Sequence Data
  • Neutrophils / cytology
  • Neutrophils / drug effects
  • Oligosaccharides / chemical synthesis
  • Oligosaccharides / chemistry
  • Oligosaccharides / pharmacology*
  • Polylysine / analogs & derivatives*
  • Polylysine / chemical synthesis
  • Polylysine / pharmacology
  • Sialyl Lewis X Antigen

Substances

  • E-Selectin
  • Ligands
  • Oligosaccharides
  • Sialyl Lewis X Antigen
  • Polylysine