Cladospolide D, a new 12-membered macrolide antibiotic produced by Cladosporium sp. FT-0012

J Antibiot (Tokyo). 2001 Aug;54(8):635-41. doi: 10.7164/antibiotics.54.635.

Abstract

A new antibiotic termed cladospolide D was isolated along with the known cladospolides A and B from the fermentation broth of Cladosporium sp. FT-0012 by solvent extraction, ODS column chromatography and preparative HPLC. The structure of cladospolide D was deduced to be (E)-2-dodecen-5-hydroxy-11-olide-4-one. Cladospolide D showed antifungal activity against Pyricularia oryzae and Mucor racemosus.

MeSH terms

  • Anti-Bacterial Agents / biosynthesis*
  • Anti-Bacterial Agents / chemistry*
  • Anti-Bacterial Agents / pharmacology
  • Antifungal Agents / chemistry
  • Antifungal Agents / pharmacology
  • Chromatography, High Pressure Liquid
  • Cladosporium / growth & development
  • Cladosporium / metabolism*
  • Cladosporium / ultrastructure
  • Fermentation
  • Macrolides*
  • Microscopy, Electron, Scanning
  • Mitosporic Fungi / drug effects
  • Molecular Structure
  • Mucor / drug effects
  • Staphylococcus aureus / drug effects
  • Xanthomonas / drug effects

Substances

  • Anti-Bacterial Agents
  • Antifungal Agents
  • Macrolides
  • cladospolide D