Abstract
A new antibiotic termed cladospolide D was isolated along with the known cladospolides A and B from the fermentation broth of Cladosporium sp. FT-0012 by solvent extraction, ODS column chromatography and preparative HPLC. The structure of cladospolide D was deduced to be (E)-2-dodecen-5-hydroxy-11-olide-4-one. Cladospolide D showed antifungal activity against Pyricularia oryzae and Mucor racemosus.
MeSH terms
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Anti-Bacterial Agents / biosynthesis*
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Anti-Bacterial Agents / chemistry*
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Anti-Bacterial Agents / pharmacology
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Antifungal Agents / chemistry
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Antifungal Agents / pharmacology
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Chromatography, High Pressure Liquid
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Cladosporium / growth & development
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Cladosporium / metabolism*
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Cladosporium / ultrastructure
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Fermentation
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Macrolides*
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Microscopy, Electron, Scanning
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Mitosporic Fungi / drug effects
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Molecular Structure
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Mucor / drug effects
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Staphylococcus aureus / drug effects
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Xanthomonas / drug effects
Substances
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Anti-Bacterial Agents
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Antifungal Agents
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Macrolides
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cladospolide D