SW-163C and E, novel antitumor depsipeptides produced by Streptomyces sp. I. Taxonomy, fermentation, isolation and biological activities

J Antibiot (Tokyo). 2001 Aug;54(8):615-21. doi: 10.7164/antibiotics.54.615.

Abstract

Novel depsipeptides, SW-163C and E were isolated from the culture broth of an actinomycete strain. The producing organism, designated as SNA15896, was identified as a member of Streptomyces from its morphological and cultural characteristics. SW-163C and E exhibited potent antitumor activities against various tumor cell lines in vitro and against murine leukemia P388 in vivo. The compounds also showed antimicrobial activities.

MeSH terms

  • Animals
  • Antibiotics, Antineoplastic / biosynthesis
  • Antibiotics, Antineoplastic / isolation & purification
  • Antibiotics, Antineoplastic / pharmacology*
  • Bacteria / drug effects
  • Cell Division / drug effects
  • Depsipeptides*
  • Fermentation
  • Fungi / drug effects
  • Leukemia P388 / drug therapy
  • Neoplasm Transplantation
  • Peptides, Cyclic*
  • Streptomyces / classification*
  • Streptomyces / growth & development
  • Streptomyces / metabolism*
  • Tumor Cells, Cultured / pathology

Substances

  • Antibiotics, Antineoplastic
  • Depsipeptides
  • Peptides, Cyclic
  • SW-163C
  • SW-163E