Abstract
Novel depsipeptides, SW-163C and E were isolated from the culture broth of an actinomycete strain. The producing organism, designated as SNA15896, was identified as a member of Streptomyces from its morphological and cultural characteristics. SW-163C and E exhibited potent antitumor activities against various tumor cell lines in vitro and against murine leukemia P388 in vivo. The compounds also showed antimicrobial activities.
MeSH terms
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Animals
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Antibiotics, Antineoplastic / biosynthesis
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Antibiotics, Antineoplastic / isolation & purification
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Antibiotics, Antineoplastic / pharmacology*
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Bacteria / drug effects
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Cell Division / drug effects
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Depsipeptides*
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Fermentation
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Fungi / drug effects
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Leukemia P388 / drug therapy
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Neoplasm Transplantation
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Peptides, Cyclic*
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Streptomyces / classification*
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Streptomyces / growth & development
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Streptomyces / metabolism*
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Tumor Cells, Cultured / pathology
Substances
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Antibiotics, Antineoplastic
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Depsipeptides
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Peptides, Cyclic
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SW-163C
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SW-163E