N,N'-bis[4-(N-alkylamidino)phenyl]homopiperazines as anti-Pneumocystis carinii agents

Bioorg Med Chem Lett. 2001 Oct 22;11(20):2679-81. doi: 10.1016/s0960-894x(01)00541-8.

Abstract

The synthesis, anti-Pneumocystis carinii activity and DNA binding properties of eight new N,N'-bis[4-(N-alkylamidino)phenyl]homopiperazines are reported. Compounds 2 and 8 were the most potent and caused about 70% inhibition of Pneumocystis carinii growth in a cell culture model at 1 microM concentrations.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Alkanes / chemical synthesis*
  • Alkanes / chemistry
  • Alkanes / pharmacology
  • Antifungal Agents / chemical synthesis*
  • Antifungal Agents / chemistry
  • Antifungal Agents / pharmacology
  • DNA / drug effects
  • DNA / metabolism
  • Microbial Sensitivity Tests
  • Piperazines / chemical synthesis*
  • Piperazines / chemistry
  • Piperazines / pharmacology*
  • Pneumocystis / drug effects

Substances

  • Alkanes
  • Antifungal Agents
  • Piperazines
  • DNA