Abstract
The synthesis, anti-Pneumocystis carinii activity and DNA binding properties of eight new N,N'-bis[4-(N-alkylamidino)phenyl]homopiperazines are reported. Compounds 2 and 8 were the most potent and caused about 70% inhibition of Pneumocystis carinii growth in a cell culture model at 1 microM concentrations.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Alkanes / chemical synthesis*
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Alkanes / chemistry
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Alkanes / pharmacology
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Antifungal Agents / chemical synthesis*
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Antifungal Agents / chemistry
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Antifungal Agents / pharmacology
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DNA / drug effects
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DNA / metabolism
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Microbial Sensitivity Tests
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Piperazines / chemical synthesis*
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Piperazines / chemistry
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Piperazines / pharmacology*
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Pneumocystis / drug effects
Substances
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Alkanes
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Antifungal Agents
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Piperazines
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DNA