Abstract
A 17-year-old male who had been diagnosed with ulcerative colitis was prescribed 80 mg prednisolone and 1,500 mg 5-aminosalicylic acid (5-ASA) per day. Two weeks after initiating therapy, he was referred to our hospital for evaluation of chest pain and high fever. Electrocardiography (ECG) showed ST elevation in limb and precordial leads. Chest pain with high fever and ECG changes were resolved after 5-ASA was discontinued. Three weeks later, the administration of a low dose of 5-ASA was associated with the immediate recurrence of pericarditis associated with chest pain, suggesting a hypersensitive reaction to 5-ASA in this patient.
MeSH terms
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Adolescent
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Anti-Inflammatory Agents / therapeutic use
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Anti-Inflammatory Agents, Non-Steroidal / adverse effects*
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Anti-Inflammatory Agents, Non-Steroidal / therapeutic use
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Colitis, Ulcerative / drug therapy*
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Echocardiography
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Electrocardiography
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Humans
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Male
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Mesalamine / adverse effects*
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Mesalamine / therapeutic use
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Pericarditis / blood
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Pericarditis / chemically induced*
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Pericarditis / diagnosis*
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Pericarditis / diagnostic imaging
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Pericarditis / physiopathology
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Prednisolone / therapeutic use
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Recurrence
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Severity of Illness Index
Substances
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Anti-Inflammatory Agents
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Anti-Inflammatory Agents, Non-Steroidal
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Mesalamine
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Prednisolone