Abstract
Five new diprenylated flavonols, broussonol A (1), broussonol B (2), broussonol C (3), broussonol D (4), and broussonol E (5), along with two known compounds, were isolated from an ethanolic extract of the leaves of Broussonetia kazinoki. Their structures were elucidated by chemical and spectral methods. Cytotoxic activities were evaluated against several different cell lines.
MeSH terms
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Dose-Response Relationship, Drug
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Drug Screening Assays, Antitumor
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Flavonoids / chemistry
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Flavonoids / isolation & purification*
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Flavonoids / pharmacology
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Humans
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Ileal Neoplasms
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KB Cells
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Lung Neoplasms
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Magnetic Resonance Spectroscopy
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Medicine, Chinese Traditional
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Molecular Conformation
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Molecular Structure
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Moraceae / chemistry*
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Plant Leaves / chemistry
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Plants, Medicinal / chemistry
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Spectrophotometry, Infrared
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Spectrophotometry, Ultraviolet
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Tumor Cells, Cultured / drug effects