Abstract
Four new monochlorinated diterpene alkaloids, haterumaimides F-I (1-4), and two known ones, dichlorolissoclimide and chlorolissoclimide, were isolated from an ascidian Lissoclinum sp. Their structures with absolute stereochemistries were elucidated by chemical and spectral analyses. Haterumaimides F-I (1-4) inhibited the first cleavage of fertilized sea urchin eggs and exhibited potent to weak cytotoxicities against P388 cells.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Alkaloids / chemistry
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Alkaloids / isolation & purification*
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Alkaloids / pharmacology
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Alkaloids / toxicity
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Animals
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Cell Division / drug effects
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Chromatography, High Pressure Liquid
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Diterpenes / chemistry
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Diterpenes / isolation & purification*
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Diterpenes / pharmacology
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Diterpenes / toxicity
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Drug Screening Assays, Antitumor
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Female
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Inhibitory Concentration 50
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Japan
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Leukemia P388
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Leukemia, Lymphoid
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Magnetic Resonance Spectroscopy
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Mass Spectrometry
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Molecular Structure
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Ovum / cytology
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Ovum / drug effects
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Ovum / metabolism
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Sea Urchins / drug effects
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Sea Urchins / embryology
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Sea Urchins / metabolism
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Spectrophotometry, Infrared
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Stereoisomerism
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Structure-Activity Relationship
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Tumor Cells, Cultured / drug effects
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Urochordata / chemistry*