Abstract
Five new bufadienolides, 3beta-formyloxyresibufogenin (1), 19-oxobufalin (2), 19-oxodesacetylcinobufagin (3), 6alpha-hydroxycinobufagin (4), and 1beta-hydroxybufalin (5), have been isolated together with the previously known bufadienolides 6-20 from the Chinese traditional drug "Ch'an Su". The structures were elucidated employing spectroscopic methods. Bufadienolides 1-5 provided significant inhibitory activity against the KB and HL-60 cancer cell lines. In addition, bufadienolide 1 was found active against the MH-60 cancer cell line.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / isolation & purification*
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Antineoplastic Agents / pharmacology
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Bufanolides / chemistry
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Bufanolides / isolation & purification*
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Bufanolides / pharmacology
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Bufonidae
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Chromatography, High Pressure Liquid
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Chromatography, Thin Layer
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HL-60 Cells / drug effects
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Humans
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KB Cells / drug effects
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Leukemia, Myeloid
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Magnetic Resonance Spectroscopy
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Medicine, Chinese Traditional
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Mice
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Molecular Conformation
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Molecular Structure
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Nasopharyngeal Neoplasms
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Skin / metabolism
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Spectrophotometry, Infrared
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Spectrophotometry, Ultraviolet
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Tumor Cells, Cultured / drug effects
Substances
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Antineoplastic Agents
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Bufanolides