Abstract
DNA polymerases require tethering to an accessory factor, typically a ring-shaped clamp, to remain bound to DNA during replication. Three recent structural studies provide unique insight into how these clamps are loaded onto DNA by the clamp loader machinery.
MeSH terms
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Adenosine Triphosphate / metabolism*
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Animals
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Binding Sites
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DNA / chemistry*
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DNA / genetics*
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DNA / metabolism
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DNA Polymerase III / metabolism
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DNA Replication*
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DNA-Binding Proteins / chemistry
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DNA-Binding Proteins / metabolism*
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DNA-Directed DNA Polymerase / metabolism*
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Escherichia coli / enzymology
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Escherichia coli / genetics
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Models, Molecular
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Protein Conformation
Substances
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DNA-Binding Proteins
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Adenosine Triphosphate
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DNA
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DNA Polymerase III
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DNA-Directed DNA Polymerase