Opening of the clamp: an intimate view of an ATP-driven biological machine

Cell. 2001 Sep 21;106(6):655-60. doi: 10.1016/s0092-8674(01)00498-6.

Abstract

DNA polymerases require tethering to an accessory factor, typically a ring-shaped clamp, to remain bound to DNA during replication. Three recent structural studies provide unique insight into how these clamps are loaded onto DNA by the clamp loader machinery.

Publication types

  • Review

MeSH terms

  • Adenosine Triphosphate / metabolism*
  • Animals
  • Binding Sites
  • DNA / chemistry*
  • DNA / genetics*
  • DNA / metabolism
  • DNA Polymerase III / metabolism
  • DNA Replication*
  • DNA-Binding Proteins / chemistry
  • DNA-Binding Proteins / metabolism*
  • DNA-Directed DNA Polymerase / metabolism*
  • Escherichia coli / enzymology
  • Escherichia coli / genetics
  • Models, Molecular
  • Protein Conformation

Substances

  • DNA-Binding Proteins
  • Adenosine Triphosphate
  • DNA
  • DNA Polymerase III
  • DNA-Directed DNA Polymerase