Comparison of the chiral resolution of econazole, miconazole, and sulconazole by HPLC using normal-phase amylose CSPs

Fresenius J Anal Chem. 2001 Aug;370(7):951-5. doi: 10.1007/s002160100884.

Abstract

Resolution of the enantiomers of (+/-)-econazole, (+/-)-miconazole, and (+/-)-sulconazole has been achieved on different normal-phase chiral amylose columns, Chi-ralpak AD, AS, and AR. The mobile phase used was hexane-2-propanol-diethylamine, 400:99:1 (v/v). The flow rates of the mobile phase used were 0.50 and 1.00 mL min(-1). The alpha values for the resolved enantiomers of econazole, miconazole, and sulconazole on the chiral phases were in the range 1.63 to 1.04; the Rs values varied from 5.68 to 0.32.

Publication types

  • Comparative Study

MeSH terms

  • Amylose / chemistry
  • Antifungal Agents / analysis*
  • Chromatography, High Pressure Liquid / methods*
  • Econazole / analysis
  • Imidazoles / analysis
  • Miconazole / analysis
  • Molecular Conformation

Substances

  • Antifungal Agents
  • Imidazoles
  • sulconazole
  • Econazole
  • Miconazole
  • Amylose