Anti-HIV activity of novel phosphonate derivatives of AZT, d4T, and ddA

Nucleosides Nucleotides Nucleic Acids. 2001 Apr-Jul;20(4-7):767-9. doi: 10.1081/NCN-100002426.

Abstract

Anti-HIV activity and cytotoxicity were tested for novel phosphonate derivatives of AZT, d4T and ddA. For d4T phosphonate derivatives the most active was 2',3'-Dideoxy-2',3'-didehydrothymidine 5'-isopropylphosphite and among the AZT phosphonate derivatives highest activity was shown by 2',3'-Dideoxy-3'-azidothymidine 5'-cyclohexylphosphite.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-HIV Agents / pharmacology*
  • Anti-HIV Agents / toxicity
  • Cell Line
  • Cell Survival / drug effects
  • Dideoxyadenosine / analogs & derivatives
  • Dideoxynucleosides / pharmacology*
  • Dideoxynucleosides / toxicity
  • HIV Core Protein p24 / analysis
  • HIV-1 / drug effects
  • HIV-1 / physiology
  • Humans
  • Immunoenzyme Techniques
  • Organophosphonates / pharmacology
  • Organophosphonates / toxicity
  • Stavudine / analogs & derivatives
  • Virus Replication / drug effects
  • Zidovudine / analogs & derivatives

Substances

  • Anti-HIV Agents
  • Dideoxynucleosides
  • HIV Core Protein p24
  • Organophosphonates
  • Zidovudine
  • Dideoxyadenosine
  • Stavudine