Abstract
Anti-HIV activity and cytotoxicity were tested for novel phosphonate derivatives of AZT, d4T and ddA. For d4T phosphonate derivatives the most active was 2',3'-Dideoxy-2',3'-didehydrothymidine 5'-isopropylphosphite and among the AZT phosphonate derivatives highest activity was shown by 2',3'-Dideoxy-3'-azidothymidine 5'-cyclohexylphosphite.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-HIV Agents / pharmacology*
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Anti-HIV Agents / toxicity
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Cell Line
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Cell Survival / drug effects
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Dideoxyadenosine / analogs & derivatives
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Dideoxynucleosides / pharmacology*
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Dideoxynucleosides / toxicity
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HIV Core Protein p24 / analysis
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HIV-1 / drug effects
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HIV-1 / physiology
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Humans
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Immunoenzyme Techniques
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Organophosphonates / pharmacology
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Organophosphonates / toxicity
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Stavudine / analogs & derivatives
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Virus Replication / drug effects
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Zidovudine / analogs & derivatives
Substances
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Anti-HIV Agents
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Dideoxynucleosides
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HIV Core Protein p24
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Organophosphonates
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Zidovudine
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Dideoxyadenosine
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Stavudine