Abstract
3'-deoxy-3'-C-trifluoromethyl- (3), 2',3'-dideoxy-3'-C-trifluoromethyl- (5) and 2',3'-dideoxy-2',3'-didehydro-3'-C-trifluoromethyladenosine (6) derivatives have been synthesized and their antiviral properties examined. All these derivatives were stereospecifically prepared by glycosylation of adenine with a trifluoromethyl sugar precursor (1), followed by appropriate chemical modifications. The prepared compounds were tested for their activity against HIV, but they did not show an antiviral effect.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Anti-HIV Agents / chemical synthesis*
-
Anti-HIV Agents / pharmacology
-
Cell Line
-
Dideoxyadenosine / analogs & derivatives*
-
Dideoxyadenosine / chemical synthesis
-
Dideoxyadenosine / pharmacology
-
HIV-1 / drug effects
-
HIV-1 / physiology
-
Humans
-
Hydrocarbons, Fluorinated / chemical synthesis
-
Hydrocarbons, Fluorinated / pharmacology
-
Stereoisomerism
-
Virus Replication / drug effects
Substances
-
Anti-HIV Agents
-
Hydrocarbons, Fluorinated
-
Dideoxyadenosine