Synthesis of 2',3'-dideoxy-2',3'-didehydro nucleosides via a serendipitous route

Nucleosides Nucleotides Nucleic Acids. 2001 Apr-Jul;20(4-7):1263-6. doi: 10.1081/NCN-100002532.

Abstract

This paper describes a "green" synthesis of 2',3'-unsaturated 2',3'-dideoxynucleosides via an electrochemical reaction. Using this approach d4T, d4U, ddA and ddI can be synthesized in high yields.

MeSH terms

  • Dideoxynucleosides / chemical synthesis*
  • Pyrimidine Nucleosides / chemical synthesis*
  • Stereoisomerism
  • Thymidine / chemical synthesis

Substances

  • Dideoxynucleosides
  • Pyrimidine Nucleosides
  • Thymidine