Photosensitized and catalytic oxidation of DNA by metallophthalocyanine-oligonucleotide conjugates

V V Koval; A A Chernonosov; T V Abramova; T M Ivanova; O S Fedorova; V M Derkacheva; E A Lukyanets

doi:10.1081/NCN-100002531

Photosensitized and catalytic oxidation of DNA by metallophthalocyanine-oligonucleotide conjugates

Nucleosides Nucleotides Nucleic Acids. 2001 Apr-Jul;20(4-7):1259-62. doi: 10.1081/NCN-100002531.

Authors

V V Koval¹, A A Chernonosov, T V Abramova, T M Ivanova, O S Fedorova, V M Derkacheva, E A Lukyanets

Affiliation

¹ Institute of Bioorganic Chemistry, Lavrentyev Ave. 8, Novosibirsk, 630090, Russia.

PMID: 11562998
DOI: 10.1081/NCN-100002531

Abstract

The synthesis of new metallophthalocyanine-oligonucleotide conjugates is reported. These conjugates can cause sequence-specific photosensitized or catalytic oxidation of DNA by molecular oxygen.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Catalysis
DNA / chemistry*
Indoles / chemical synthesis
Indoles / chemistry*
Isoindoles
Oligonucleotides / chemical synthesis
Oligonucleotides / chemistry*
Organometallic Compounds / chemical synthesis
Organometallic Compounds / chemistry*
Oxidation-Reduction
Photochemistry
Radiation-Sensitizing Agents / chemical synthesis
Radiation-Sensitizing Agents / chemistry*

Substances

Indoles
Isoindoles
Oligonucleotides
Organometallic Compounds
Radiation-Sensitizing Agents
DNA
phthalocyanine