Abstract
2,6-Dichloro-1-deazapurine and 2,6-dichloro-3-deazapurine were coupled with 1,2-O-diacetyl-5-O-benzoyl-3-deoxy-beta-D-ribofuranose. Deprotection of the obtained compounds and reaction with liquid ammonia gave the desired 2-chloroadenine nucleosides, which were dechlorinated to afford the corresponding 1-deaza and 3-deazaadenosine derivatives. Biological studies performed on ADA from calf intestine showed that these new nucleosides are inhibitors of the enzyme.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adenosine / analogs & derivatives*
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Adenosine / pharmacology
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Adenosine Deaminase Inhibitors*
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Animals
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Cattle
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Deoxyribose / analogs & derivatives*
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Deoxyribose / chemistry
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Deoxyribose / pharmacology
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Enzyme Inhibitors / chemical synthesis
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Enzyme Inhibitors / chemistry*
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Enzyme Inhibitors / pharmacology*
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Intestines / enzymology
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Kinetics
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Magnetic Resonance Spectroscopy
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Spectrophotometry, Ultraviolet
Substances
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Adenosine Deaminase Inhibitors
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Enzyme Inhibitors
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Deoxyribose
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Adenosine