Interventional therapies are a valuable addition to our armamentarium when treating myofascial pain syndromes. When combined with other therapies, interventional techniques can be an effective adjunct in the multidisciplinary management of pain. This article describes current interventional therapies that are employed in treating myofascial pain syndromes. The mainstay of injection therapies, the myofascial trigger point injection, is emphasized. More recent advances, such as the use of botulinum toxin, are also discussed. In addition, other techniques such as acupuncture and the use of laser therapy are mentioned.