Abstract
Five unique metabolites, xyloketals A (1), B (2), C (3), D (4), and E (5), and the known 6 were isolated from mangrove fungus Xylaria sp. (no. 2508), obtained from the South China Sea. The structures of these compounds were elucidated by spectroscopic and X-ray diffraction experiments. Xyloketal A is a ketal compound with a C(3) symmetry and xyloketals B-E are its analogues. It was found that xytoketal C slowly rearranged to xytoketal B in DMSO-d(6)() solution at room temperature. Xyloketal A exhibited the activity of inhibiting acetylcholine esterase.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acetylcholinesterase / drug effects
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Asia, Southeastern
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Biological Factors / administration & dosage
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Biological Factors / chemistry*
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Biological Factors / isolation & purification*
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Cholinesterase Inhibitors / chemistry
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Cholinesterase Inhibitors / isolation & purification*
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Cholinesterase Inhibitors / pharmacology*
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Fungi / chemistry*
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Marine Biology
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Pyrans / isolation & purification*
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Pyrans / pharmacology*
Substances
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Biological Factors
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Cholinesterase Inhibitors
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Pyrans
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xyloketal A
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Acetylcholinesterase