Abstract
In this (1)H-MRS follow-up study of the medial temporal lobe (MTL) in patients with AD, the authors report a correlation of N-acetylaspartate (NAA)/creatine (Cr) with cognitive decline. Severely progressed patients showed a reduction, whereas stable or mildly progressed subjects showed a slight increase of NAA/Cr. The reduction of NAA/Cr in the MTL represents a correlate of cognitive deterioration in AD, whereas it is of limited use to detect subtle changes over time in clinically stable patients.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Aged
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Alzheimer Disease / metabolism*
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Alzheimer Disease / psychology
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Aspartic Acid / analogs & derivatives
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Aspartic Acid / metabolism*
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Cognition Disorders / metabolism*
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Cognition Disorders / psychology
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Creatine / metabolism*
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Cross-Sectional Studies
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Female
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Follow-Up Studies
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Humans
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Magnetic Resonance Spectroscopy
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Male
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Mental Status Schedule
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Middle Aged
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Statistics, Nonparametric
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Temporal Lobe / metabolism*
Substances
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Aspartic Acid
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N-acetylaspartate
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Creatine