Contractile properties of rat skeletal muscles after hindlimb unloading and beta-GPA administration

G A Nasledov; R S Arutyunyan; T L Nemirovskaya; B S Shenkman; I B Kozlovskaya

Contractile properties of rat skeletal muscles after hindlimb unloading and beta-GPA administration

J Gravit Physiol. 1996 Sep;3(2):11-2.

Authors

G A Nasledov¹, R S Arutyunyan, T L Nemirovskaya, B S Shenkman, I B Kozlovskaya

Affiliation

¹ Sechenov Institute of Evolutionary Physiology and Biochemistry, St. Petersburg, Russia.

PMID: 11540263

Abstract

NASA: Soleus and EDL muscles of rats were examined following hindlimb unloading. Some of the rats were given beta-GPA, a creatine analog which depletes high-energy phosphates in muscle tissue, in their food. The contractile properties and fatigue resistance of these muscles were studied, with and without incubation in calcium solution. The increased fatigue resistance after beta-GPA feeding was less in calcium-free solution.

Publication types

Comparative Study

MeSH terms

Animals
Calcium / deficiency*
Guanidines / pharmacology*
Hindlimb Suspension / adverse effects*
Male
Muscle Contraction / drug effects
Muscle Contraction / physiology*
Muscle Fatigue / drug effects*
Muscle Fatigue / physiology
Muscle, Skeletal / drug effects
Muscle, Skeletal / metabolism*
Muscle, Skeletal / physiology
Propionates / pharmacology*
Rats
Rats, Wistar

Substances

Guanidines
Propionates
Calcium
guanidinopropionic acid