Abstract
From their discovery in the first half of the 20th century, lysosomal cysteine proteases have come a long way: from being the enzymes non-selectively degrading proteins in lysosomes to being those responsible for a number of important cellular processes. Some of the features and roles of their structures, specificity, regulation and physiology are discussed.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Amino Acid Sequence
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Animals
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Cathepsins / metabolism
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Cysteine Endopeptidases / chemistry*
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Cysteine Endopeptidases / metabolism*
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Humans
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Lysosomes / enzymology*
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Models, Molecular
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Molecular Sequence Data
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Papain / chemistry
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Protein Conformation
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Protein Structure, Secondary
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Sequence Alignment
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Sequence Homology, Amino Acid
Substances
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Cathepsins
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Cysteine Endopeptidases
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Papain