Cutaneous mastocytosis associated with a mixed germ cell tumour of the ovary: report of a case and review of the literature

Br J Dermatol. 2001 Aug;145(2):309-12. doi: 10.1046/j.1365-2133.2001.04322.x.

Abstract

A 10-year-old girl with a mixed germ cell tumour of the ovary, treated by surgery and chemotherapy, developed cutaneous mastocytosis approximately 8 months after starting chemotherapy. This is the sixth report of a germ cell tumour associated with mastocytosis. c-kit receptor point mutations, including Asp816Val and Val560Gly were absent in a biopsy specimen obtained from lesional skin.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Child
  • Female
  • Germinoma / complications*
  • Germinoma / drug therapy
  • Humans
  • Mastocytosis / complications*
  • Ovarian Neoplasms / complications*
  • Ovarian Neoplasms / drug therapy
  • Point Mutation / genetics
  • Polymerase Chain Reaction / methods
  • Proto-Oncogene Proteins c-kit / genetics

Substances

  • Proto-Oncogene Proteins c-kit