Abstract
A 10-year-old girl with a mixed germ cell tumour of the ovary, treated by surgery and chemotherapy, developed cutaneous mastocytosis approximately 8 months after starting chemotherapy. This is the sixth report of a germ cell tumour associated with mastocytosis. c-kit receptor point mutations, including Asp816Val and Val560Gly were absent in a biopsy specimen obtained from lesional skin.
MeSH terms
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Antineoplastic Combined Chemotherapy Protocols / therapeutic use
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Child
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Female
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Germinoma / complications*
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Germinoma / drug therapy
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Humans
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Mastocytosis / complications*
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Ovarian Neoplasms / complications*
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Ovarian Neoplasms / drug therapy
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Point Mutation / genetics
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Polymerase Chain Reaction / methods
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Proto-Oncogene Proteins c-kit / genetics
Substances
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Proto-Oncogene Proteins c-kit