Imidazolopyrazinones as potential antioxidants

Bioorg Med Chem Lett. 2001 Sep 3;11(17):2305-9. doi: 10.1016/s0960-894x(01)00445-0.

Abstract

A series of imidazolopyrazinones 3, substituted at C-2, and C-2/C-6, has been prepared. The compounds behaved as quenchers of superoxide anion. The more active compounds are structurally related to coelenterazine, a natural substrate of marine bioluminescence. Theoretical parameters based on Hartree-Fock instabilities have been examined.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antioxidants / chemistry*
  • Antioxidants / metabolism
  • Antioxidants / pharmacology*
  • Drug Evaluation, Preclinical
  • Imidazoles*
  • Magnetic Resonance Spectroscopy
  • Molecular Structure
  • Pyrazines / chemistry
  • Pyrazoles / chemistry
  • Reactive Oxygen Species
  • Structure-Activity Relationship
  • Superoxides / metabolism

Substances

  • Antioxidants
  • Imidazoles
  • Pyrazines
  • Pyrazoles
  • Reactive Oxygen Species
  • Superoxides
  • coelenterazine