Abstract
A series of imidazolopyrazinones 3, substituted at C-2, and C-2/C-6, has been prepared. The compounds behaved as quenchers of superoxide anion. The more active compounds are structurally related to coelenterazine, a natural substrate of marine bioluminescence. Theoretical parameters based on Hartree-Fock instabilities have been examined.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antioxidants / chemistry*
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Antioxidants / metabolism
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Antioxidants / pharmacology*
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Drug Evaluation, Preclinical
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Imidazoles*
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Magnetic Resonance Spectroscopy
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Molecular Structure
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Pyrazines / chemistry
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Pyrazoles / chemistry
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Reactive Oxygen Species
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Structure-Activity Relationship
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Superoxides / metabolism
Substances
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Antioxidants
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Imidazoles
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Pyrazines
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Pyrazoles
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Reactive Oxygen Species
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Superoxides
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coelenterazine