Are Alzheimer's disease patients able to learn visual prototypes?

Neuropsychologia. 2001;39(11):1218-23. doi: 10.1016/s0028-3932(01)00046-x.

Abstract

Recently, controversial results emerged regarding visual prototype learning in Alzheimer's disease (AD). The aim of this study was to elucidate this issue in a larger population of AD patients. The AD patients (N=72) and age-matched healthy control subjects (N=25) learned to recognize and to categorize visual dot patterns. In comparison with the control subjects, the AD patients as a group showed dysfunctions in the recognition task, whereas categorization was relatively spared in their case. Recognition was impaired in patients with mild AD (Mini-Mental score: 18-23) and moderate AD (Mini-Mental score<18), whereas categorization was impaired only in patients with moderate AD. These results suggest that while the medio-temporal/diencephalic explicit memory system is markedly affected even in early AD, the sensory neocortical areas mediating implicit category learning display a sufficient degree of functional capacity until later stages of the disease.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Alzheimer Disease / physiopathology*
  • Brain / physiopathology*
  • Functional Laterality / physiology
  • Humans
  • Learning / physiology*
  • Memory Disorders / diagnosis
  • Memory Disorders / physiopathology
  • Neuropsychological Tests*
  • Perceptual Disorders / diagnosis*
  • Perceptual Disorders / physiopathology*
  • Recognition, Psychology
  • Visual Perception / physiology*