Abstract
Lower urinary tract function was studied in patients with Parkinson's disease. A significant proportion of patients receiving levodopa manifested clinical and radiological evidence of bladder outlet obstruction. We believe that neuropharmacologic bladder neck obstruction may be caused by the alpha-adrenergic properties of the metabolites of levodopa.
MeSH terms
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3,4-Dihydroxyphenylacetic Acid / pharmacology
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Aged
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Dopamine / pharmacology
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Female
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Homovanillic Acid / pharmacology
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Humans
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Levodopa / adverse effects*
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Male
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Middle Aged
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Parkinson Disease / complications*
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Parkinson Disease / drug therapy
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Ureter / surgery
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Urinary Bladder / pathology
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Urinary Bladder / surgery
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Urinary Bladder Neck Obstruction / chemically induced*
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Urination / drug effects
Substances
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3,4-Dihydroxyphenylacetic Acid
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Levodopa
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Dopamine
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Homovanillic Acid