New jatrophane diterpenoid esters from Euphorbia turczaninowii

J Nat Prod. 2001 Aug;64(8):1064-8. doi: 10.1021/np010015q.

Abstract

Five new (1-5) and one known (6) jatrophane diterpenoid esters were isolated from the ethanol extract of the whole herb of Euphorbia turczaninowii. Their structures were established by extensive spectroscopic methods. The absolute stereochemistry of 3 beta,5 alpha,8 alpha,15 beta-tetraacetoxy-7 beta-benzoyloxyjatropha-6(17),11E-dien-9,14-dione (1) was confirmed by a single-crystal X-ray analysis coupled with the exciton chirality circular dichroism method. Compounds 1-6 were inactive when evaluated both in a mouse ear inflammation assay and for cytotoxicity against the B16 mouse melanoma cell line.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antineoplastic Agents, Phytogenic / chemistry
  • Antineoplastic Agents, Phytogenic / isolation & purification*
  • Antineoplastic Agents, Phytogenic / pharmacology
  • Chromatography, Thin Layer
  • Crystallography, X-Ray
  • Diterpenes / chemistry
  • Diterpenes / isolation & purification*
  • Diterpenes / pharmacology
  • Drugs, Chinese Herbal / chemistry
  • Drugs, Chinese Herbal / isolation & purification*
  • Drugs, Chinese Herbal / pharmacology
  • Ear
  • Euphorbiaceae / chemistry*
  • Magnetic Resonance Spectroscopy
  • Melanoma, Experimental
  • Mice
  • Molecular Conformation
  • Molecular Structure
  • Plants, Medicinal / chemistry*
  • Spectrophotometry, Ultraviolet
  • Spectroscopy, Fourier Transform Infrared
  • Tumor Cells, Cultured / drug effects
  • Tumor Cells, Cultured / metabolism

Substances

  • 3beta,5alpha,7beta,8alpha-pentaacetoxy-2alpha-benzoyloxyjatropha-6(17),11E-dien-9,14-dione
  • 3beta,5alpha,8alpha,15beta-tetraacetoxy-7beta-benzoyloxyjatropha-6(17),11E-dien-9,14-dione
  • Antineoplastic Agents, Phytogenic
  • Diterpenes
  • Drugs, Chinese Herbal