Aminoglycoside-modifying enzymes: mechanisms of catalytic processes and inhibition

E Azucena; S Mobashery

doi:10.1054/drup.2001.0197

Aminoglycoside-modifying enzymes: mechanisms of catalytic processes and inhibition

Drug Resist Updat. 2001 Apr;4(2):106-17. doi: 10.1054/drup.2001.0197.

Authors

E Azucena¹, S Mobashery

Affiliation

¹ Institute for Drug Design, Departments of Chemistry, Pharmacology and Biochemistry and Molecular Biology, Wayne State University, Detroit, Michigan, USA.

PMID: 11512519
DOI: 10.1054/drup.2001.0197

Abstract

The most prevalent mechanism for resistance to aminoglycoside antibiotics is mediated through their enzymatic modification in resistant organisms. Dozens of aminoglycoside-modifying enzymes are known at the gene sequence level, but few have been characterized in the details of their mechanism. This review summarizes the state of knowledge of the best studied of these enzymes, focusing on their catalytic mechanisms and inhibition.

Publication types

Review

MeSH terms

Acetyltransferases / chemistry
Acetyltransferases / metabolism*
Aminoglycosides
Animals
Anti-Bacterial Agents / chemistry
Anti-Bacterial Agents / metabolism*
Anti-Bacterial Agents / pharmacology
Catalytic Domain / drug effects
Catalytic Domain / physiology*
Drug Resistance, Bacterial / physiology
Humans
Kanamycin Kinase / chemistry
Kanamycin Kinase / metabolism*
Nucleotidyltransferases / chemistry
Nucleotidyltransferases / metabolism*

Substances

Aminoglycosides
Anti-Bacterial Agents
Acetyltransferases
aminoglycoside acetyltransferase
Kanamycin Kinase
Nucleotidyltransferases