Development of a low-metal adhesive tape to detect and localize metals in or on the stratum corneum at parts per million levels

Skin Pharmacol Appl Skin Physiol. 2001:14 Suppl 1:46-51. doi: 10.1159/000056390.

Abstract

Tape-stripping is a well-established method for sampling the stratum corneum (SC). We have developed a tape with low-metal content suitable for use with particle-induced X-ray emission (PIXE), an analytical technique based on X-ray spectrometry. PIXE analysis of tape-stripped samples of SC is a reliable and minimally invasive means of identifying and quantifying metals present at parts per million levels. Assay feasibility and reproducibility was demonstrated using human volunteers. This new tape-strip technique has potential applications in exposure and decontamination assessment, diagnosis of metal dermatitis, forensics, and in environmental research.

Publication types

  • Clinical Trial
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Adhesives / chemistry*
  • Humans
  • Metals / chemistry*
  • Skin / chemistry*
  • Spectrometry, X-Ray Emission

Substances

  • Adhesives
  • Metals