Peptides corresponding to the heptad repeat motifs in the transmembrane protein (gp41) of human immunodeficiency virus type 1 elicit antibodies to receptor-activated conformations of the envelope glycoprotein

E de Rosny; R Vassell; P T Wingfield; C T Wild; C D Weiss

doi:10.1128/jvi.75.18.8859-8863.2001

Peptides corresponding to the heptad repeat motifs in the transmembrane protein (gp41) of human immunodeficiency virus type 1 elicit antibodies to receptor-activated conformations of the envelope glycoprotein

J Virol. 2001 Sep;75(18):8859-63. doi: 10.1128/jvi.75.18.8859-8863.2001.

Authors

E de Rosny¹, R Vassell, P T Wingfield, C T Wild, C D Weiss

Affiliation

¹ Office of Vaccines, Center for Biologics Evaluation and Research (CBER), Food and Drug Administration (FDA), Bethesda, Maryland 20892-4555, USA.

Abstract

Two heptad repeat regions in the ectodomain of the human immunodeficiency virus type 1 (HIV-1) transmembrane subunit (gp41) self-assemble into a six-helix bundle structure that is critical for virus entry. Immunizations with peptides corresponding to these regions generated antibodies specific to the receptor-activated conformations of gp41.

MeSH terms

Amino Acid Sequence
Animals
CD4 Antigens / immunology*
Cell Line, Transformed
HIV Antibodies / immunology*
HIV Envelope Protein gp41 / chemistry
HIV Envelope Protein gp41 / immunology*
HIV-1 / immunology*
Humans
Molecular Sequence Data
Peptides / chemistry
Peptides / immunology*
Protein Conformation*
Rabbits
Repetitive Sequences, Nucleic Acid

Substances

CD4 Antigens
HIV Antibodies
HIV Envelope Protein gp41
Peptides