Delayed post-irradiation bulbar palsy in nasopharyngeal carcinoma

Neurology. 2001 Aug 14;57(3):529-31. doi: 10.1212/wnl.57.3.529.

Abstract

In a hospital series of 70 patients on follow-up after radiotherapy for nasopharyngeal carcinoma, 14 patients (20%) developed delayed post-irradiation bulbar palsy 1 to 18 years after radiotherapy (mean 5.5 years). Functional disability was moderate to severe. Three patients had aspiration pneumonia with one mortality. Post-irradiation bulbar palsy was a common complication and probably resulted from direct neuronal damage.

MeSH terms

  • Adult
  • Bulbar Palsy, Progressive / etiology*
  • Bulbar Palsy, Progressive / physiopathology
  • Cranial Irradiation / adverse effects*
  • Electromyography
  • Female
  • Humans
  • Male
  • Middle Aged
  • Nasopharyngeal Neoplasms / physiopathology
  • Nasopharyngeal Neoplasms / radiotherapy*
  • Time Factors