Time course of recovery of the somatosensory map following hindpaw sensory deprivation in the rat

Neurosci Lett. 2001 Aug 24;309(2):121-4. doi: 10.1016/s0304-3940(01)02050-x.

Abstract

Hindlimb sensory deprivation is known to induce a decrease in the cortical representation of hindpaw, and an increase in the size of the cutaneous receptive fields. The aim of the present study was to determine (i) the time-course of recovery when the rat retrieves a normal use of its limbs after a 14-day period of sensory disruption and (ii) whether a 1-day period of sensory deprivation is sufficient to induce a plasticity. Our results indicate that the remodelling of the cortical map was not observed after 1 day of sensory deprivation. On the other hand, the recovery was achieved after 6 h. These findings suggest that a procedure reducing sensory function resulted in reversible changes in the somatosensory cortex. The recovery was more rapid than the induction of plasticity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Brain Mapping
  • Hindlimb / innervation
  • Immobilization
  • Male
  • Neuronal Plasticity / physiology
  • Rats
  • Rats, Wistar
  • Recovery of Function / physiology*
  • Sensory Deprivation / physiology*
  • Somatosensory Cortex / physiology*
  • Touch / physiology*
  • Weightlessness Simulation