Polymorphism of CYP450 and cancer susceptibility

X M Han; H H Zhou

Polymorphism of CYP450 and cancer susceptibility

Acta Pharmacol Sin. 2000 Aug;21(8):673-9.

Authors

X M Han¹, H H Zhou

Affiliation

¹ Pharmacogenetics Research Institute, Basic and Clinical Pharmacology Institute, Hunan Medical University, Changsha 410078, China.

PMID: 11501173

Abstract

CYP450s form a superfamily involved in the metabolism of many endogenous and exogenous substrates. In this review, the substrates, probe drugs, genetic polymorphisms, and associated cancers of CYP1A1, CYP1A2, CYP2C19, CYP2D6, CYP2E1, and CYP3A4 are summarized.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Breast Neoplasms / genetics
Carcinoma, Hepatocellular / genetics
Cytochrome P-450 Enzyme System / genetics*
Genetic Predisposition to Disease
Genotype
Humans
Liver Neoplasms / genetics
Lung Neoplasms / genetics
Phenotype
Polymorphism, Genetic

Substances

Cytochrome P-450 Enzyme System