Abstract
In acute experiments, the effects of iontophoretically applied 17 beta-estradiol hemisuccinate on the activity of the primary somatosensory cortical neurons were studied in ovariectomized rats by extracellular single-unit recording. 17 beta-Estradiol increased both the spontaneous and the vibrissa deflection-evoked responses, with an average latency of 24 min. It is suggested that this relatively long latency of the 17 beta-estradiol effect is based not so much on membrane mechanisms as on genomic mechanisms.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Electrophysiology
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Estradiol / pharmacology*
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Evoked Potentials, Somatosensory / drug effects
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Female
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Glutamic Acid / pharmacology
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Iontophoresis
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Neuronal Plasticity / drug effects
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Neurons / drug effects*
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Neurons / physiology
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Ovariectomy
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Rats
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Rats, Sprague-Dawley
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Somatosensory Cortex / cytology*
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Somatosensory Cortex / physiology
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Vibrissae / innervation
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gamma-Aminobutyric Acid / pharmacology
Substances
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Glutamic Acid
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Estradiol
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gamma-Aminobutyric Acid