Drug-induced linear IgA bullous disease following antibiotics

Australas J Dermatol. 2001 Aug;42(3):196-9. doi: 10.1046/j.1440-0960.2001.00515.x.

Abstract

A 69-year-old woman presented with pneumonia and subacute bacterial endocarditis. Nine days after intravenous vancomycin and ciprofloxacin were commenced, the patient developed a bullous mucocutaneous eruption. Clinical presentation and histopathology were consistent with drug-induced linear IgA bullous disease (LABD). The patient's lesions resolved with cessation of antibiotics. A review of the features of drug-induced LABD and the drugs that have been implicated are presented.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Anti-Bacterial Agents / administration & dosage
  • Anti-Bacterial Agents / adverse effects*
  • Anti-Infective Agents / administration & dosage
  • Anti-Infective Agents / adverse effects*
  • Arm
  • Ciprofloxacin / administration & dosage
  • Ciprofloxacin / adverse effects*
  • Drug Eruptions / etiology*
  • Drug Eruptions / pathology
  • Endocarditis, Bacterial / complications
  • Endocarditis, Bacterial / drug therapy
  • Female
  • Foot
  • Humans
  • Infusions, Intravenous
  • Pneumonia / complications
  • Pneumonia / drug therapy
  • Skin Diseases, Vesiculobullous / chemically induced*
  • Skin Diseases, Vesiculobullous / pathology
  • Vancomycin / administration & dosage
  • Vancomycin / adverse effects*

Substances

  • Anti-Bacterial Agents
  • Anti-Infective Agents
  • Ciprofloxacin
  • Vancomycin