Abstract
A 69-year-old woman presented with pneumonia and subacute bacterial endocarditis. Nine days after intravenous vancomycin and ciprofloxacin were commenced, the patient developed a bullous mucocutaneous eruption. Clinical presentation and histopathology were consistent with drug-induced linear IgA bullous disease (LABD). The patient's lesions resolved with cessation of antibiotics. A review of the features of drug-induced LABD and the drugs that have been implicated are presented.
MeSH terms
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Aged
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Anti-Bacterial Agents / administration & dosage
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Anti-Bacterial Agents / adverse effects*
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Anti-Infective Agents / administration & dosage
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Anti-Infective Agents / adverse effects*
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Arm
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Ciprofloxacin / administration & dosage
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Ciprofloxacin / adverse effects*
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Drug Eruptions / etiology*
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Drug Eruptions / pathology
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Endocarditis, Bacterial / complications
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Endocarditis, Bacterial / drug therapy
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Female
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Foot
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Humans
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Infusions, Intravenous
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Pneumonia / complications
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Pneumonia / drug therapy
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Skin Diseases, Vesiculobullous / chemically induced*
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Skin Diseases, Vesiculobullous / pathology
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Vancomycin / administration & dosage
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Vancomycin / adverse effects*
Substances
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Anti-Bacterial Agents
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Anti-Infective Agents
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Ciprofloxacin
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Vancomycin