High frequency of the HIV-1 protective CCR5 delta32 deletion in native Estonians

I Kalev; A V Mikelsaar; L Beckman; G Tasa; P Pärlist

doi:10.1023/a:1010829816334

High frequency of the HIV-1 protective CCR5 delta32 deletion in native Estonians

Eur J Epidemiol. 2000;16(12):1107-9. doi: 10.1023/a:1010829816334.

Authors

I Kalev¹, A V Mikelsaar, L Beckman, G Tasa, P Pärlist

Affiliation

¹ Department of Human Biology and Genetics, Institute of General and Molecular Pathology, University of Tartu, Estonia.

PMID: 11484798
DOI: 10.1023/a:1010829816334

Abstract

In previous studies, the highest frequencies (16%) of the CCR5 delta32 deletion have been found in populations of Finno-Ugric origin. We here report a high CCR5 delta32 frequency (15%) in another Finno-Ugric populations, the Estonians. The highest frequency (18%) was found on the geographically isolated Estonian island of Dagö. We examined 504 healthy unrelated individuals of Estonian nationality, whose grandparents were born in Estonia. The polymerase chain reaction assay was performed and the amplified products were digested with EcoRI.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Base Sequence
Estonia
Female
Gene Deletion*
Gene Frequency
Genetics, Population*
HIV Infections / genetics*
HIV Infections / prevention & control
HIV-1 / genetics*
Humans
Male
Molecular Sequence Data
Polymerase Chain Reaction
Polymorphism, Genetic
Population Surveillance
Receptors, CCR5 / genetics*

Substances

Receptors, CCR5