Abstract
[reaction: see text] 2,5-Disubstituted oxazoles have been prepared through the reaction of N-propargylamides with aryl iodides in the presence of Pd(2)(dba)(3), tri(2-furyl)phosphine, and NaO(t)()Bu. The reaction appears to proceed through a palladium-catalyzed coupling step followed by the in situ cyclization of the resultant coupling product.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amides / chemical synthesis*
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Catalysis
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Cyclization
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Indicators and Reagents
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Oxazoles / chemical synthesis*
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Palladium / chemistry
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Pargyline / analogs & derivatives*
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Pargyline / chemical synthesis*
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Solvents
Substances
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Amides
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Indicators and Reagents
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Oxazoles
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Solvents
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Palladium
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Pargyline