Abstract
[reaction: see text] Suzuki coupling of 18 and 30 affords 9 as an interconverting mixture of two atropisomers. Treatment with LDA at -23 degrees C affords the macrocyclic ketone 8 in 57% yield.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Antineoplastic Agents / chemical synthesis*
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Antineoplastic Agents / chemistry
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Cyclization
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Heterocyclic Compounds, 4 or More Rings / chemical synthesis*
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Heterocyclic Compounds, 4 or More Rings / chemistry
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Indicators and Reagents
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Magnetic Resonance Spectroscopy
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Marine Toxins / chemical synthesis*
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Marine Toxins / chemistry
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Oxazoles / chemical synthesis*
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Oxazoles / chemistry
Substances
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Antineoplastic Agents
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Heterocyclic Compounds, 4 or More Rings
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Indicators and Reagents
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Marine Toxins
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Oxazoles
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diazonamide A