Evolution of a synthetic approach to CP-263,114

J T Njardarson; J L Wood

doi:10.1021/ol015978v

Evolution of a synthetic approach to CP-263,114

Org Lett. 2001 Aug 9;3(16):2431-4. doi: 10.1021/ol015978v.

Authors

J T Njardarson¹, J L Wood

Affiliation

¹ Sterling Chemistry Laboratory, Department of Chemistry, Yale University, New Haven, Connecticut 06520-8107, USA.

PMID: 11483027
DOI: 10.1021/ol015978v

Abstract

[structure: see text] Three different approaches to the carbocyclic core of CP-263,114 are presented that illustrate a strategic evolution from an oxy-Cope rearrangement to variants of the Wharton fragmentation.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Chemical Phenomena
Chemistry, Physical
Enzyme Inhibitors / chemical synthesis*
Indicators and Reagents
Maleic Anhydrides / chemical synthesis*
Stereoisomerism

Substances

CP 263114
Enzyme Inhibitors
Indicators and Reagents
Maleic Anhydrides