Abstract
Four novel cyclic homodecapetide antibiotics, streptocidins A-D were detected in the mycelium extract of Streptomyces sp. Tü 6071 by HPLC-diode-array and HPLC-electrospray-mass-spectrometry screening. The peptides which were closely related in structure to the tyrocidines and gramicidins of Bacillus brevis show antibiotic activities against Gram-positive bacteria.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Anti-Bacterial Agents / isolation & purification*
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Anti-Bacterial Agents / pharmacology*
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Chromatography, High Pressure Liquid
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DNA, Bacterial / genetics
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DNA, Ribosomal / genetics
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Gram-Negative Bacteria / drug effects*
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Gram-Positive Bacteria / drug effects*
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Microbial Sensitivity Tests
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Peptides, Cyclic / isolation & purification*
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Peptides, Cyclic / pharmacology*
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Sequence Analysis, DNA
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Spectrometry, Mass, Electrospray Ionization
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Streptomyces / chemistry*
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Streptomyces / genetics
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Streptomyces / metabolism
Substances
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Anti-Bacterial Agents
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DNA, Bacterial
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DNA, Ribosomal
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Peptides, Cyclic
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streptocidin A
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streptocidin B
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streptocidin C
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streptocidin D