Abstract
Gene expression is regulated by transcription factors binding selectively to particular portions of the genome. To what extent are these protein-DNA interactions influenced by the intrinsic sequence-specific recognition properties at each protein, and to what extent are they affected by other factors, such as chromatin structure or cooperative interactions with other proteins. Genome-wide surveys of DNA binding by transcription factors in vivo are beginning to provide some answers.
MeSH terms
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Animals
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Chromatin / metabolism
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Cross-Linking Reagents / pharmacology
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DNA / metabolism*
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Drosophila / genetics
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Gene Expression Regulation / physiology*
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Humans
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Protein Binding / drug effects
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Protein Binding / physiology*
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Protein Binding / radiation effects
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Saccharomyces cerevisiae / genetics
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Substrate Specificity / genetics
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Transcription Factors / metabolism*
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Transcription, Genetic / physiology
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Ultraviolet Rays
Substances
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Chromatin
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Cross-Linking Reagents
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Transcription Factors
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DNA