Antitumor agents. Synthesis and biological evaluation of new compounds related to podophyllotoxin, containing the 2,3-dihydro-1,4-benzodioxin system

A S Capilla; I Sánchez; D H Caignard; P Renard; M D Pujol

doi:10.1016/s0223-5234(01)01231-4

Antitumor agents. Synthesis and biological evaluation of new compounds related to podophyllotoxin, containing the 2,3-dihydro-1,4-benzodioxin system

Eur J Med Chem. 2001 Apr;36(4):389-93. doi: 10.1016/s0223-5234(01)01231-4.

Authors

A S Capilla¹, I Sánchez, D H Caignard, P Renard, M D Pujol

Affiliation

¹ Laboratoire de Química Farmacèutica, Faculté de Farmàcia, Universitat de Barcelona, Av. Diagonal 643, E-08028 Barcelona, Spain.

PMID: 11461764
DOI: 10.1016/s0223-5234(01)01231-4

Abstract

New compounds with naphtho-fused systems were synthesized and evaluated as antitumor agents. The naphtho-fused systems 6 and 7, synthesized from the hydroxy-acetal, exhibit antitumor activity. The bis(phenylthio) derivatives were considered as possible precursors for lignan lactones (11). The hydroxy-naphthalen 6 showed a significant antineoplastic activity.

MeSH terms

Antineoplastic Agents / chemistry*
Antineoplastic Agents / pharmacology*
Biochemistry / methods
Cell Division / drug effects
Drug Screening Assays, Antitumor
Humans
Inhibitory Concentration 50
Naphthalenes / chemistry*
Naphthalenes / pharmacology*
Podophyllotoxin / chemistry*
Podophyllotoxin / pharmacology
Structure-Activity Relationship
Tumor Cells, Cultured

Substances

Antineoplastic Agents
Naphthalenes
Podophyllotoxin