The metabolic environment determines the characteristics of fibrin network structure (FNS) in plasma. Physical activity or changes in the diet (e.g., high and low glycemic index meals) can initiate these changes. The FNS were measured by means of mass-length ratio, turbidity, and compaction of the plasma obtained from male subjects. Samples were taken before and after the introduction of the different diets and physical activity. The results indicate that changes in the FNS do occur, but further investigation is required to obtain conclusive results.