Cloning and heterologous expression of the macrotetrolide biosynthetic gene cluster revealed a novel polyketide synthase that lacks an acyl carrier protein

J Am Chem Soc. 2001 Apr 11;123(14):3385-6. doi: 10.1021/ja0100827.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Acyl Carrier Protein / chemistry
  • Acyl Carrier Protein / genetics*
  • Acyl Carrier Protein / metabolism
  • Alcohol Oxidoreductases / chemistry
  • Alcohol Oxidoreductases / genetics
  • Alcohol Oxidoreductases / metabolism
  • Anti-Bacterial Agents / biosynthesis*
  • Bacterial Proteins*
  • Base Sequence
  • Cloning, Molecular
  • DNA, Bacterial / genetics
  • Gene Expression
  • Macrolides
  • Molecular Sequence Data
  • Multienzyme Complexes / chemistry
  • Multienzyme Complexes / genetics*
  • Multienzyme Complexes / metabolism
  • Multigene Family*
  • Streptomyces griseus / enzymology
  • Streptomyces griseus / genetics

Substances

  • Acyl Carrier Protein
  • Anti-Bacterial Agents
  • Bacterial Proteins
  • DNA, Bacterial
  • Macrolides
  • Multienzyme Complexes
  • Alcohol Oxidoreductases
  • polyketide synthase ketoreductase

Associated data

  • GENBANK/AF074603
  • GENBANK/AF263011
  • GENBANK/AF263012