Abstract
A new cytotoxic 1,7-dioxa-dispiro[5.1.5.2]pentadeca-9,12-dien-11-one derivative, aculeatin D, and a new alkenone, 5-hydroxy-hexacos-1-en-3-one, have been isolated as minor compounds from the rhizomes of Amomum aculeatum. Their structures have been determined mainly by NMR spectroscopy and mass spectrometry. Aculeatin D showed high cytotoxicity against the KB and the L-6 cell line with IC(50) of 0.38 microg/ml and 1 microg/ml, respectively. Additionally, it revealed remarkable activity against two Plasmodium falciparum strains, as well as against Trypanosoma brucei rhodesiense and Trypanosoma cruzi. 5-Hydroxy-hexacos-1-en-3-one exhibited neither cytotoxic nor antiprotozoal activity, whereas antibacterial testing against Bacillus cereus, Escherichia coli and Staphylococcus epidermidis showed moderate to strong activity for both compounds.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alkenes / chemistry
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Alkenes / isolation & purification*
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Alkenes / pharmacology
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Animals
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Anti-Infective Agents / chemistry
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Anti-Infective Agents / isolation & purification*
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Anti-Infective Agents / pharmacology
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Antifungal Agents / chemistry
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Antifungal Agents / isolation & purification
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Antifungal Agents / pharmacology
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / isolation & purification*
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Antineoplastic Agents, Phytogenic / pharmacology
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Antiprotozoal Agents / chemistry
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Antiprotozoal Agents / isolation & purification
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Antiprotozoal Agents / pharmacology
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Cell Line
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Drug Screening Assays, Antitumor
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Humans
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Inhibitory Concentration 50
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Ketones / chemistry
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Ketones / isolation & purification*
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Ketones / pharmacology
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Magnetic Resonance Spectroscopy
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Mass Spectrometry
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Microbial Sensitivity Tests
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New Guinea
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Plant Stems / chemistry
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Plants, Medicinal / chemistry*
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Rats
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Spiro Compounds / chemistry
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Spiro Compounds / isolation & purification*
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Spiro Compounds / pharmacology
Substances
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1,7-dioxa-dispiro(5.1.5.2)pentadeca-9,12-dien-11-one
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5-hydroxy-hexacos-1-en-3-one
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Alkenes
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Anti-Infective Agents
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Antifungal Agents
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Antineoplastic Agents, Phytogenic
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Antiprotozoal Agents
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Ketones
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Spiro Compounds